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Archive / FAA Pilot’s Handbook of Aeronautical Knowledge / Pilot’s Handbook: Chapter 17 — Aeromedical Factors

Chapter 17, Part 3

Aeromedical Factors — Part 3

FAA-H-8083-25C (2023)

Fatigue

Fatigue is frequently associated with pilot error. Some of

the effects of fatigue include degradation of attention and

concentration, impaired coordination, and decreased ability

to communicate. These factors seriously influence the

ability to make effective decisions. Physical fatigue results

from sleep loss, exercise, or physical work. Factors such as

stress and prolonged performance of cognitive work result

in mental fatigue.

Like stress, fatigue falls into two broad categories: acute

and chronic. Acute fatigue is short term and is a normal

occurrence in everyday living. It is the kind of tiredness

people feel after a period of strenuous effort, excitement, or

lack of sleep. Rest after exertion and 8 hours of sound sleep

ordinarily cures this condition.

A special type of acute fatigue is skill fatigue. This type of

fatigue has two main effects on performance:

• Timing disruption—appearing to perform a task as

usual, but the timing of each component is slightly off.

This makes the pattern of the operation less smooth

because the pilot performs each component as though it

were separate, instead of part of an integrated activity.

• Disruption of the perceptual field—concentrating

attention upon movements or objects in the center of

vision and neglecting those in the periphery. This is

accompanied by loss of accuracy and smoothness in

control movements.

Acute fatigue has many causes, but the following are among

the most important for the pilot:

• Mild hypoxia (oxygen deficiency)

• Physical stress

• Psychological stress

• Depletion of physical energy resulting from

psychological stress

• Sustained psychological stress

Sustained psychological stress accelerates the glandular

secretions that prepare the body for quick reactions during

an emergency. These secretions make the circulatory and

respiratory systems work harder, and the liver releases energy

to provide the extra fuel needed for brain and muscle work.

When this reserve energy supply is depleted, the body lapses

into generalized and severe fatigue.

Acute fatigue can be prevented by proper diet and adequate

rest and sleep. A well-balanced diet prevents the body from

needing to consume its own tissues as an energy source.

Adequate rest maintains the body’s store of vital energy.

Chronic fatigue, extending over a long period of time, usually

has psychological roots, although an underlying disease is

sometimes responsible. Continuous high-stress levels produce

chronic fatigue. Chronic fatigue is not relieved by proper diet

and adequate rest and sleep and usually requires treatment

by a physician. An individual may experience this condition

in the form of weakness, tiredness, palpitations of the heart,

breathlessness, headaches, or irritability. Sometimes chronic

fatigue even creates stomach or intestinal problems and

generalized aches and pains throughout the body. When the

condition becomes serious enough, it leads to emotional illness.

If suffering from acute fatigue, stay on the ground. If fatigue

occurs in the flight deck, no amount of training or experience

can overcome the detrimental effects. Getting adequate rest

is the only way to prevent fatigue from occurring. Avoid

flying without a full night’s rest, after working excessive

hours, or after an especially exhausting or stressful day. Pilots

who suspect they are suffering from chronic fatigue should

consult a physician.

Exposure to Chemicals

When conducting preflight and post-flight inspections, pilots

must verify that the fluid levels in their aircraft meet the

levels specified for safe operations as stated in the Pilot's

Operating Handbook. These fluids include, but are not limited

to hydraulic fluid, engine oil, and fuel.

It is important that every pilot recognize the potential hazards

of working with these fluids as well as the recommended first

aid measures to follow should any of these fluids come in

contact with their eyes, skin, and/or respiratory system. As

the specific first aid measures for dealing with exposure to

these chemicals can vary by chemical type, it is important that

every pilot be familiar with the location and use of the Material

Safety Data Sheet (MSDS) for each chemical they encounter.

The procedures described in the following sections are

minimum guideline for first aid for each of the indicated

scenarios. Ultimately, the pilot should consult the MSDS

for first aid procedures specific to the type of chemical and

exposure scenario.

Hydraulic Fluid

• Eye Contact—immediately flush the eyes with clean

water and seek medical attention if irritation occurs.

• Skin Contact—remove all contaminated clothing and

thoroughly cleanse the affected areas with mild soap

and water or a waterless hand cleaner. If irritation or

redness develops and persists, seek medical attention.

Should the hydraulic fluid get into or under the skin,

or into any other part of the body, regardless of the

appearance of the wound or its size, seek medical

attention immediately.

• Inhalation—if respiratory symptoms develop, move

away from the source of exposure and into fresh air

in a position comfortable for breathing. If symptoms

persist, seek medical attention.

• Ingestion—first aid is not normally required; however,

if swallowed and symptoms develop, seek medical

attention.

Engine Oil

• Eye Contact—immediately flush the eyes with clean

water and seek medical attention if irritation occurs.

• Skin Contact—remove all contaminated clothing and

thoroughly cleanse the affected areas with soap and

water. Launder contaminated clothing before reuse.

• Inhalation—move away from the source of exposure

and into fresh air. If respiratory irritation, dizziness,

nausea, or unconsciousness occurs, seek immediate

medical attention. If breathing stops, assisted

ventilation is required via a bag-valve-mask or

cardiopulmonary resuscitation (CPR).

• Ingestion—seek immediate medical attention. If

immediate medical attention is not available, contact

a regional poison control center or emergency medical

professional regarding the induction of vomiting or

use of activated charcoal. Vomiting should never be

induced to a person who is groggy or unconscious.

Fuel

• Eye Contact—immediately flush the eyes with

clean water for at least 15 minutes and seek medical

attention immediately.

• Skin Contact—remove all contaminated clothing

and thoroughly cleanse the affected areas with mild

soap and water or a waterless hand cleaner. If skin

surface is damaged, apply a clean dressing and seek

medical attention. If irritation or redness develops,

seek medical attention. Launder contaminated clothing

before reuse.

• Inhalation—move away from the source of exposure

and into fresh air. If breathing stops, assisted

ventilation is required via a bag-valve-mask or

cardiopulmonary resuscitation (CPR). Once breathing

is restored, the use of additional oxygen may be

necessary. Seek medical attention immediately.

• Ingestion—seek immediate medical attention. Do not

induce vomiting or take anything by mouth as this may

cause the material to enter the lungs and cause severe

lung damage. Should vomiting occur, keep head below

the hips to reduce the risks of aspiration. Monitor for

breathing difficulties. Rinse out any material which

enters the mouth until the taste is dissipated.

Dehydration and Heatstroke

Dehydration is the term given to a critical loss of water from

the body. Causes of dehydration are hot flight decks and

flight lines, wind, humidity, and diuretic drinks—coffee, tea,

alcohol, and caffeinated soft drinks. Some common signs of

dehydration are headache, fatigue, cramps, sleepiness, and

dizziness.

The first noticeable effect of dehydration is fatigue, which

in turn makes top physical and mental performance difficult,

if not impossible. Flying for long periods in hot summer

temperatures or at high altitudes increases the susceptibility

to dehydration because these conditions tend to increase the

rate of water loss from the body.

To help prevent dehydration, drink two to four quarts of

water every 24 hours. Since each person is physiologically

different, this is only a guide. Most people are aware of the

eight-glasses-a-day guide: If each glass of water is eight

ounces, this equates to 64 ounces, which is two quarts. If

this fluid is not replaced, fatigue progresses to dizziness,

weakness, nausea, tingling of hands and feet, abdominal

cramps, and extreme thirst.

The key for pilots is to be continually aware of their condition.

Most people become thirsty with a 1.5 quart deficit or a loss

of 2 percent of total body weight. This level of dehydration

triggers the “thirst mechanism.” The problem is that the thirst

mechanism arrives too late and is turned off too easily. A

small amount of fluid in the mouth turns this mechanism off

and the replacement of needed body fluid is delayed.

Other steps to prevent dehydration include:

• Carrying a container in order to measure daily water

intake.

• Staying ahead—not relying on the thirst sensation as

an alarm. If plain water is not preferred, add some

sport drink flavoring to make it more acceptable.

• Limiting daily intake of caffeine and alcohol (both are

diuretics and stimulate increased production of urine).

Heatstroke is a condition caused by any inability of the body

to control its temperature. Onset of this condition may be

recognized by the symptoms of dehydration, but also has

been known to be recognized only upon complete collapse.

Type Beverage Typical Serving Pure Alcohol

(oz) Content (oz)

Table wine

Light beer

Aperitif liquor

Champagne

Vodka

Whiskey

4.0

12.0

1.5

4.0

1.0

1.25

.48

.48

.38

.48

.50

.50

0.01–0.05% average individual appears normal

(10–50 mg)

0.03–0.12%* mild euphoria, talkativeness, decreased

(30–120 mg) inhibitions, decreased attention, impaired

judgment, increased reaction time

0.09–0.25% emotional instability, loss of critical

(90–250 mg) judgment, impairment of memory and

comprehension, decreased sensory

response, mild muscular incoordination

0.18–0.30% confusion, dizziness, exaggerated

(180–300 mg) emotions (anger, fear, grief), impaired

visual perception, decreased pain

sensation, impaired balance, staggering

gait, slurred speech, moderate muscular

incoordination

0.27–0.40% apathy, impaired consciousness, stupor,

(270–400 mg) significantly decreased response to

stimulation, severe muscular

incoordination, inability to stand or walk,

vomiting, incontinence of urine and feces

0.35–0.50% unconsciousness, depressed or

(350–500 mg) abolished reflexes, abnormal body

temperature, coma, possible death from

respiratory paralysis (450 mg or above)

* Legal limit for motor vehicle operation in most states is 0.08

or 0.10% (80–100 mg of alcohol per dL of blood).

Figure 17-8. Impairment scale with alcohol use.

To prevent these symptoms, it is recommended that an

ample supply of water be carried and used at frequent

intervals on any long flight, whether thirsty or not. The body

normally absorbs water at a rate of 1.2 to 1.5 quarts per hour.

Individuals should drink one quart per hour for severe heat

stress conditions or one pint per hour for moderate stress

conditions. If the aircraft has a canopy or roof window,

wearing light-colored, porous clothing and a hat will help

provide protection from the sun. Keeping the flight deck well

ventilated aids in dissipating excess heat.

Alcohol

Alcohol impairs the efficiency of the human body.

[Figure 17-8] Studies have shown that consuming alcohol

is closely linked to performance deterioration. Pilots must

make hundreds of decisions, some of them time-critical,

during the course of a flight. The safe outcome of any flight

depends on the ability to make the correct decisions and take

the appropriate actions during routine occurrences, as well

as abnormal situations. The influence of alcohol drastically

reduces the chances of completing a flight without incident.

Even in small amounts, alcohol can impair judgment,

decrease sense of responsibility, affect coordination, constrict

visual field, diminish memory, reduce reasoning ability, and

lower attention span. As little as one ounce of alcohol can

decrease the speed and strength of muscular reflexes, lessen

the efficiency of eye movements while reading, and increase

the frequency at which errors are committed. Impairments

in vision and hearing can occur from consuming as little as

one drink.

The alcohol consumed in beer and mixed drinks is ethyl

alcohol, a central nervous system depressant. From a medical

point of view, it acts on the body much like a general

anesthetic. The “dose” is generally much lower and more

slowly consumed in the case of alcohol, but the basic effects

on the human body are similar. Alcohol is easily and quickly

absorbed by the digestive tract. The bloodstream absorbs

about 80 to 90 percent of the alcohol in a drink within 30

minutes when ingested on an empty stomach. The body

requires about 3 hours to rid itself of all the alcohol contained

in one mixed drink or one beer.

While experiencing a hangover, a pilot is still under the

influence of alcohol. Although a pilot may think he or she is

functioning normally, motor and mental response impairment

is still present. Considerable amounts of alcohol can remain

in the body for over 16 hours, so pilots should be cautious

about flying too soon after drinking.

Altitude multiplies the effects of alcohol on the brain. When

combined with altitude, the alcohol from two drinks may have

the same effect as three or four drinks. Alcohol interferes

with the brain’s ability to utilize oxygen, producing a form

of histotoxic hypoxia. The effects are rapid because alcohol

passes quickly into the bloodstream. In addition, the brain

is a highly vascular organ that is immediately sensitive to

changes in the blood’s composition. For a pilot, the lower

oxygen availability at altitude and the lower capability of

the brain to use the oxygen that is available can add up to a

deadly combination.

Intoxication is determined by the amount of alcohol in the

bloodstream. This is usually measured as a percentage by

weight in the blood. 14 CFR part 91 requires that blood

alcohol level be less than .04 percent and that 8 hours pass

between drinking alcohol and piloting an aircraft. A pilot with

a blood alcohol level of .04 percent or greater after 8 hours

cannot fly until the blood alcohol falls below that amount.

Even though blood alcohol may be well below .04 percent,

a pilot cannot fly sooner than 8 hours after drinking alcohol.

Although the regulations are quite specific, it is a good idea

to be more conservative than the regulations.

Drugs

The Federal Aviation Regulations include no specific

references to medication usage. Two regulations, though,

are important to keep in mind. Title 14 of the CFR part 61,

section 61.53 prohibits acting as pilot-in-command or in any

other capacity as a required pilot flight crewmember, while

that person:

1. Knows or has reason to know of any medical condition

that would make the person unable to meet the

requirement for the medical certificate necessary for

the pilot operation, or

2. Is taking medication or receiving other treatment for

a medical condition that results in the person being

unable to meet the requirements for the medical

certificate necessary for the pilot operation.

Further, 14 CFR part 91, section 91.17 pro hibits the use

of any drug that affects the person’s faculties in any way

contrary to safety.

There

are several thousand medications currently approved

by the U.S. Food and Drug Administration (FDA), not

including OTC (over the counter) drugs. Virtually all

medications

have the potential for adverse side effects in

some people. Additionally, herbal and dietary supplements,

sport and energy boosters, and some other “natural” products

are derived

from substances often found in medications that

could also have adverse side effects. While some individuals

experience

no side effects with a particular drug or product,

others may be noticeably affected. The FAA regularly

r

eviews FDA and other data to assure that medications found

acceptable

for aviation duties do not pose an adverse safety

risk. Drugs that cause no apparent side effects on the ground

can create

serious problems at even relatively low altitudes.

Even at typical general aviation altitudes, the changes in

concentrations of atmospheric gases in the blood can enhance

the

effects of seemingly innocuous drugs that can result in

impaired judgment, decision-making, and performance. In

addition, fatigue, stress, dehydration, and inadequate nutrition

can increase an airman’s susceptibility to adverse effects from

various drugs, even if they appeared to tolerate them in the

past. If multiple medications are being taken at the same time,

the adverse effects can be even more pronounced.

Ano ther important consideration is that the medical

condition

for which a medication is prescribed may itself be

disqualifying. The FAA will consider the condition in the

context

of risk for medical incapacitation, and the medication

as well for cognitive impairment, and either or both could be

found

unacceptable for medical certification.

Some of the most commonly used OTC drugs, antihistamines

and decongestants, have the poten tial to cause noticeable

adverse side effects, including drowsiness and cognitive

deficits. The symptoms associated with common

upper respiratory infections, including the common

cold,

often suppress a pilot’s desire to fly, and treating

symptoms with a drug that causes adverse side effects

only compo unds the problem. Particularly,

medications

containing diphenhydramine (e.g.,

Benadryl) are known to cause drowsiness and have a

prolonged half-life, meaning the drugs stay in one’s system

for an extended time, which lengthens the time that side

effects are present.

Many medications, such as tranquilizers, sedatives, strong

pain relievers, and cough suppressants, have primary

effects

that may impair judgment, memory, alertness,

coordination,

vision, and the ability to make calculations.

[Figure 17-9] Others, such as antihistamines, blood pressure

drugs,

muscle relaxants, and agents to control diarrhea and

motion sickness, have side effects that may impair the same

critical functions. Any medication that depresses the nervous

system, such as a sedative, tranquilizer, or antihistamine, can

make a pilot more susceptible to hypoxia.

Painkillers are grouped into two broad categories: analgesics

and

anesthetics. Analgesics are drugs that reduce pain,

while anesthetics are drugs that deaden pain or cause loss

of consciousness.

Over-the-counter analgesics, such as acetylsalicylic

acid (aspirin), acetaminophen (Tylenol), and ibuprofen

(Advil), have few side effects when taken in the

correct

dosage. Although some people are allergic to certain

analgesics or may suffer from stomach irritation, flying

usually is not restricted when taking these drugs. However,

flying is almost always precluded while using prescription

analgesics, such as drugs containing propoxyphene (e.g.,

Darvon),

oxycodone (e.g., Percodan), meperidine (e.g.,

Demerol),

and codeine, since these drugs are known to

cause side effects, such as mental confusion, dizziness,

headaches, nausea, and vision problems.

Anesthetic

drugs are commonly used for dental and surgical

procedures. Most local anesthetics used for minor dental and

outpatient procedures wear off within a relatively short period

of

time. The anesthetic itself may not limit flying as much

as the actual procedure and subsequent pain.

There is evidence taking illicit drugs significantly elevates

the risk of having an aviation accident. Even though the

Drug Enforcement Administration (DEA) defines

marijuana as a Schedule I drug on its controlled substances

list, states have taken steps to allow the possession, sale,

Figure 17-9. Adverse affects of various drugs.

Substance Possible Side Effects Generic Or

Brand Name

Treatment

for

Alcohol

Nicotine

Amphetamines

Caffeine

Antacid

Antihistamines

Aspirin

Beer

Liquor

Wine

Cigars

Cigarettes

Pipe tobacco

Chewing tobacco

Snuff

Ritalin

Obetrol

Eskatrol

Coffee

Tea

Chocolate

No-Doz

Alka-2

Di-Gel

Maalox

Coricidin

Contac

Dristan

Dimetapp

Omade

Chlor-Trimeton

Diphenhydramine

Bayer

Bufferin

Alka-Seltzer

N/A

N/A

Obesity (diet pills)

Tiredness

N/A

Stomach acids

Allergies

Colds

Headaches

Fevers

Aches

Pains

Impaired judgment and perception

Impaired coordination and motor control

Reduced reaction time

Impaired sensory perception

Reduced intellectual functions

Reduced tolerance to G-forces

Inner-ear disturbance and spatial disorientation (up to 48 hours)

Central nervous system depression

Sinus and respiratory system infection and irritation

Impaired night vision

Hypertension

Carbon monoxide poisoning (from smoking)

Prolonged wakefulness

Nervousness

Impaired vision

Suppressed appetite

Shakiness

Excessive sweating

Rapid heart rate

Sleep disturbance

Seriously impaired judgment

Impaired judgment

Reduced reaction time

Sleep disturbance

Increased motor activity and tremors

Hypertension

Irregular heart rate

Rapid heart rate

Body dehydration (through increased urine output)

Headaches

Liberations of carbon dioxide at altitude (distension may cause

acute abdominal pain and may mask other medical problems)

Drowsiness and dizziness (sometimes recurring)

Visual disturbances (when medications also contain antispasmodic drugs)

Irregular body temperature

Variation in rate and depth of respiration

Hypoxia and hyperventilation (two aspirin can contribute to)

Nausea, ringing in ears, deafness, diarrhea, and hallucinations when taken in

excessive dosages

Corrosive action on the stomach lining

Gastrointestinal problems

Decreased clotting ability of the blood (clotting ability could be the difference

between life and death in a survival situation)

and use of marijuana withing their border. The

FAA has stated, "Marijuana is an illicit drug per

federal law and its use by airmen is pro hibited."

Stimulants are drugs that excite the cen tral nerv ous

system and produce an increase in alertness and activity.

Amphetamines, caffeine, and nicotine are all forms of

stimulants. Common uses of these drugs include appetite

suppression, fatigue reduction, and mood elevation. Some

of these drugs may cause a stimulant reaction, even though

this reaction is not their primary function. In some cases,

stimulants can produce anxiety and mood swings, both of

which are dangerous when flying.

Depressants are drugs that reduce the body’s functioning in

many areas. These drugs lower blood pressure, reduce mental

processing, and slow motor and reaction responses. There are

several types of drugs that can cause a depressing effect on the

body, including

tranquilizers, motion sickness medication,

some types of stomach medication, decongestants, and

antihistamines. The most common depressant is alcohol.

Some drugs that are classified as neither stimulants nor

depressants have adverse effects on flying. For example,

some antibiotics can produce dangerous side effects, such

as balance disorders, hearing loss, nausea, and vomiting.

While many antibiotics are safe for use while flying, the

infection requiring the antibiotic may prohibit flying. In

addition, unless specifically prescribed by a physician, do

not take more than one drug at a time, and never mix drugs

with alcohol because the effects are often unpredictable.

The dangers of illegal drugs also are well documented.

Certain illegal drugs can have hallucinatory effects that occur

days or weeks after the drug is taken. Obviously, these drugs

have no place in the aviation community.

14 CFR prohibits pilots from performing crewmember

duties while using any medication that affects the body in

any way contrary to safety. The safest rule is not to fly as a

crewmember while taking any medication, unless approved to

do so by the FAA. If there is any doubt regarding the effects

of any medication, consult an AME before flying.

Prior to each and every flight, all pilots must do a proper

physical self-assessment to ensure safety. A great mnemonic,

covered in Chapter 2 on Aeronautical Decision-Making,

is IMSAFE, which stands for Illness, Medication, Stress,

Alcohol, Fatigue, and Emotion.

For the medication component of IMSAFE, pilots need to

ask themselves, “Am I taking any medicines that might affect

my judgment or make me drowsy? For any new medication,

OTC or prescribed, you should wait at least 48 hours after

the first dose before flying to determine you do not have any

adverse side effects that would make it unsafe to operate an

aircraft. In addition to medication questions, pilots should

also consider the following –

• Do not take any unnecessary or elective medications;

• Make sure you eat regular balanced meals;

• Bring a snack for both you and your passengers for

the flight;

• Maintain good hydration - bring plenty of water;

• Ensure adequate sleep the night prior to the flight; and

• Stay physically fit.

Additionally, you should wait at least five maximal dosing

intervals, the time between recommended or prescribed

dosing, (e.g., a dosing interval of 5 to 6 hours would require

you to wait 30 hours) before flying after taking any medication

that has potentially adverse side effects (e.g., sedating or

dizziness). Observing the recommended dosing interval

doesn’t eliminate the risk for adverse side effects because

everyone metabolizes medications differently. However,

five times the dosing interval is a reasonable rule of thumb.

Altitude-Induced Decompression Sickness (DCS)

Decompression sickness (DCS) describes a condition

characterized by a variety of symptoms resulting from

exposure to low barometric pressures that cause inert gases

(mainly nitrogen), normally dissolved in body fluids and

tissues, to come out of physical solution and form bubbles.

Nitrogen is an inert gas normally stored throughout the

human body (tissues and fluids) in physical solution. When

the body is exposed to decreased barometric pressures (as in

flying an unpressurized aircraft to altitude or during a rapid

decompression), the nitrogen dissolved in the body comes out

of solution. If the nitrogen is forced to leave the solution too

rapidly, bubbles form in different areas of the body causing a

variety of signs and symptoms. The most common symptom

is joint pain, which is known as “the bends.” [Figure 17-10]

What to do when altitude-induced DCS occurs:

• Put on oxygen mask immediately and switch the

regulator to 100 percent oxygen.

• B egin an emergency descent and land as soon as

possible. Even if the symptoms disappear during

descent, land and seek medical evaluation while

continuing to breathe oxygen.

• If one of the symptoms is joint pain, keep the affected

area still; do not try to work pain out by moving the

joint around.

• Upon landing, seek medical assistance from an FAA

medical officer, AME, military flight surgeon, or

a hyperbaric medicine specialist. Be aware that a

physician not specialized in aviation or hypobaric

medicine may not be familiar with this type of medical

problem.

• Definitive medical treatment may involve the use of

a hyperbaric chamber operated by specially-trained

personnel.

• Delayed signs and symptoms of altitude-induced DCS

can occur after return to ground level regardless of

presence during flight.

DCS After Scuba Diving

Scuba diving subjects the body to increased pressure, which

allows more nitrogen to dissolve in body tissues and fluids.

[Figure 17-11] The reduction of atmospheric pressure that

accompanies flying can produce physical problems for scuba

divers. A pilot or passenger who intends to fly after scuba

diving should allow the body sufficient time to rid itself of

excess nitrogen absorbed during diving. If not, DCS due to

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